منابع مشابه
Enzymatic mechanism of GPI anchor attachment clarified
A group of eukaryotic cell surface proteins are anchored to the outer leaflet of the plasma membrane by glycosylphosphatidylinositol (GPi). in human cells, about 150 GPi-anchored proteins of various functions, such as hydrolytic enzymes, receptors, protease inhibitors, adhesion molecules, and complement regulatory proteins, have been known, and more will be added to the list. GPi is a glycolipi...
متن کاملGPI-anchor synthesis is indispensable for the germline development of the nematode Caenorhabditis elegans
Glycosylphosphatidylinositol (GPI)-anchor attachment is one of the most common posttranslational protein modifications. Using the nematode Caenorhabditis elegans, we determined that GPI-anchored proteins are present in germline cells and distal tip cells, which are essential for the maintenance of the germline stem cell niche. We identified 24 C. elegans genes involved in GPI-anchor synthesis. ...
متن کاملMutations in PIGO, a member of the GPI-anchor-synthesis pathway, cause hyperphosphatasia with mental retardation.
Hyperphosphatasia with mental retardation syndrome (HPMRS), an autosomal-recessive form of intellectual disability characterized by facial dysmorphism, seizures, brachytelephalangy, and persistent elevated serum alkaline phosphatase (hyperphosphatasia), was recently shown to be caused by mutations in PIGV, a member of the glycosylphosphatidylinositol (GPI)-anchor-synthesis pathway. However, not...
متن کاملDefects in glycosylphosphatidylinositol (GPI) anchor synthesis activate Hog1 kinase and confer copper-resistance in Saccharomyces cerevisisae.
Las21/Gpi7 contains a heavy-metal-associated motif at its N-terminus. When this motif was disrupted by amino acid substitution, the cells acquired weak copper-resistance. We found that the previously isolated las21 mutants were strongly resistant to copper. Metallothionein is necessary for the expression of the copper-resistance of the las21 mutants. However, hyper-production of metallothionein...
متن کاملGPI-anchor and GPI-anchored protein expression in PMM2-CDG patients
BACKGROUND Mutations in PMM2 impair phosphomannomutase-2 activity and cause the most frequent congenital disorder of glycosylation, PMM2-CDG. Mannose-1-phosphate, that is deficient in this disorder, is also implicated in the biosynthesis of glycosylphosphatidyl inositol (GPI) anchors. OBJECTIVE To evaluate whether GPI-anchor and GPI-anchored proteins are defective in PMM2-CDG patients. METH...
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ژورنال
عنوان ژورنال: Developmental Cell
سال: 2004
ISSN: 1534-5807
DOI: 10.1016/j.devcel.2004.05.011